Life Eze Plus with SAMe

HISTORY OF SAMe
SAMe was first brought to attention by an Italian, Cantoni in 1951. It was an unstable molecule and could not be studied in clinical trials until it became commercially available in 1974. An Italian group devised a way of stabilising SAMe. Since then numerous studies have been carried out showing that SAMe participates in a variety of biological reactions. SAMe has been used clinically in Europe since the 1970’s and is today one of the most used supplements for stress, nervous tension, mild anxiety and low mood in Europe. Strong evidence exists that SAMe is effective for the treatment of low mood and mild anxiety. Some studies have suggested a faster onset of action for SAMe than for conventional antidepressants.2 As SAMe research pioneer G. Stramentinol notes; “SAMe is an important physiologic compound that occurs in every living cell.”3

LIFTING ANXIETY, STRESS AND LOW MOOD SAMe has experimentally been shown to be effective with those suffering from low mood disorders. SAMe stimulates the activity of chemical messenger pathways in

the brain. Levels of SAMe have been shown to be reduced in the redblood cells of those with low mood, suggesting a disruption in SAMe pathways. This has formed the basis for the use of SAMe for the relief of stress and associated conditions, particularly those suffering with a low mood. A popular psychological ratings scale has shown the effect of SAMe in patients suffering from mild anxiety and associated health problems to be consistent with improvement in mood.4

OSTEOARTHRITIS The potential benefit of using SAMe in osteoarthritis was discovered when patients enrolled in clinical trials of SAMe for depression reported marked improvement in

their symptoms associated with osteoarthritis. Nine clinical trials in Europe and one in the United States with a total of more than 22 000 participants have confirmed the therapeutic activity of SAMe against osteoarthritis.4 To date, a total of 22,261 patients have participated in clinical trials for the temporary relief of osteoarthrits. 21,524 were given SAMe, 458 were given different non steroidal anti inflammatory drugs (NSAID’s) and 279 given a placebo. The trials were conducted over a period of three weeks to two years and dosages ranged from 400 – 1200mg daily.2

HELPS LIVER FUNCTION The potential benefit of SAMe in assisting poor liver function stems from several important aspects of SAMe metabolism. In mammals, as much as 80% of the

methionine, (an essential amino acid) in the liver is converted into SAMe. Hepatic glutathione, an antioxidant made by the liver, which is dependent on methionine and SAMe metabolism, is one of the principal antioxidants involved in liver detoxification. The literature on the clinical potential of SAMe in assisting poor liver function has been the subject of several review articles.4

SAMe is able to increase the main cellular anti-oxidant levels in the liver by activating a detoxification pathway, which is known to be low in those who may have a sluggish liver, rendering it effective in this area.5

LifeEZE PLUS gives you relief in three ways;
1 For the relief of stress, nervous tension and mild anxiety.
2 Helps to support and protect the liver.
3 Provides temporary relief of the pain associated with osteoarthritis.